Focusing on the schematic illustration in a, two DNA polymerase molecules are active at the fork at any one time. One moves continuously to produce the new daughter DNA molecule on the leading strand, ...

As DNA strands ravel and unravel in an intricate dance, one notable event takes center stage: replication. This process is essential to life, but the finer details of its orchestrated steps are still ...

During replication, DNA polymerases are positioned on each strand of DNA. Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 21 (May 24, 2016), pp. 5916-5921 (6 pages) DNA replication occurs semidiscontinuously due to the ...

They require CTF18-RFC in humans and Ctf18-RFC in yeast to thread a ring-shaped clamp onto the DNA leading strand, and another clamp loader called RFC in both human and yeast to thread the clamp onto ...