Proteins are the molecular machines of cells. They are produced in protein factories called ribosomes based on their blueprint—the genetic information. Here, the basic building blocks of proteins, ...

Protein detection sensitivity has historically lagged behind nucleic acid detection by 2-3 orders of magnitude due to the lack of intrinsic signal amplification. While digital methods such as Single ...

Swedish chemist Jöns Jacob Berzelius, in a letter to a fellow chemist, first suggested the name ‘proteins’ for a particular class of biological substances, deriving it from the Greek word proteios, ...

Learn how experts in various techniques, such as surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC), measure protein–protein interactions (PPIs) for therapeutic development.

Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its role ...

New findings from Karolinska Institutet reveal how the gene HNRNPU coordinates several fundamental molecular processes during ...

The rapid advancement of artificial intelligence (AI) is transforming the field of structural biology. In May 2024, DeepMind and Isomorphic Labs launched AlphaFold 3 (AF3), a revolutionary AI system ...

LL-37 continues to attract scientific interest due to its unique structural characteristics and its diverse interactions within biological systems. As the only known cathelicidin-derived peptide, LL-3 ...

Scientists have uncovered new DNA-binding proteins from some of the most extreme environments on Earth and shown that they ...

Protein folding helpers such as TRiC and prefoldin (PFD) are crucial for the correct folding of many essential proteins. In a Nature study, researchers from the Max Planck Institute of Biochemistry ...