Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with ...
The result is one molecule that can be both a checkpoint degrader and a cancer vaccine ( Nature 2026, DOI: 10.1038/s41586-025 ...
Proteasomes are molecular machines for breaking down proteins. Drugmakers are working to coopt this process with targeted therapies. This story was originally published on BioPharma Dive. To receive ...
The startup is developing a medicine that can very specifically degrade cancerous forms of EGFR, the target of an array of ...
Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems to eliminate disease-causing proteins. Innovators are making rapid and ...
Targeted protein degradation has moved well beyond its prologue more than 20 years ago. 1 The number of publications describing different PROTACs (PROteolysis TArgeting Chimeras), molecular glues, and ...
Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for ...
Morning Overview on MSN
1 protein block slowed cancer in mice, and it’s a promising target
Researchers have identified a single protein whose absence can cripple tumors in mice, slowing their growth and in some cases ...
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