The thymus prevents autoimmunity by inducing apoptosis of the T cells that express autoreactive receptors to self peptides. But this mechanism alone is insufficient and CD4+CD25+ regulatory T cells ...

The cell fate decisions of developing thymocytes are coordinated by interactions with self-peptide–MHC complexes that are displayed by various types of thymic antigen presenting cells (APCs).

The thymus is the primary site of T-cell development. It consists of a series of stromal microenvironments that guide the differentiation of developing thymocytes into self-tolerant T cells. T-cell ...

Grb2 is an adaptor molecule that mediates Ras-MAPK activation induced by various receptors. Here we show that conditional ablation of Grb2 in thymocytes severely impairs both thymic positive and ...

Data support the development of Tolerance Bio’s thymic cells and pharmacological approaches for thymus regeneration in aging-related diseases, including cancer PHILADELPHIA, October 27, ...

BERLIN — The health of a cancer patient’s thymus could be linked to survival outcomes with immunotherapy, regardless of the tumor type and independent of established tumor-based biomarkers, suggests ...

The Greeks believed your thymus was home to your soul. In fact, thymus means “soul” in Greek. While no studies have proved that to be the case, your thymus does play an important role in your immune ...

Tolerance Bio’s Implanted iPSC-derived Thymic Organoids Enable In Vivo Positive Selection of Human T cells and Tumor Burden Reduction in Melanoma Patient-specific human immune system-bearing mouse ...